Gain of function in Jak2V617F-positive T-cells
نویسندگان
چکیده
منابع مشابه
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متن کاملTNFα facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms.
Proinflammatory cytokines such as TNFα are elevated in patients with myeloproliferative neoplasms (MPN), but their contribution to disease pathogenesis is unknown. Here we reveal a central role for TNFα in promoting clonal dominance of JAK2(V617F) expressing cells in MPN. We show that JAK2(V617F) kinase regulates TNFα expression in cell lines and primary MPN cells and TNFα expression is correla...
متن کاملMYELOID NEOPLASIA TNF facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms
1Division of Hematology and Medical Oncology, Oregon Health & Science University (OHSU) Knight Cancer Institute, Portland, OR; 2Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria; 3Division of Pediatric Hematology and Oncology, Department of Pediatrics, OHSU, Portland, OR; 4Department of Pathology, OSHU, Portland, OR; 5Cen...
متن کاملMMP2 gene-735 C/T and MMP9 gene -1562 C/T polymorphisms in JAK2V617F positive myeloproliferative disorders.
BACKGROUND Myeloproliferative disorders (MPDs) are clonal hematologic malignancies originating at the level of the pluripotent hematopoietic stem cell. Matrix metalloproteases (MMPs) are proteolytic enzymes that contribute to all stages of malignancy progression. Genetic variants in the MMP genes may influence the biological function of these enzymes and change their role in carcinogenesis and ...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2017
ISSN: 0887-6924,1476-5551
DOI: 10.1038/leu.2017.6